Raquel Sofia Andre Santos Silva
- Bioinformatician, Genomics
Publications
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07/2026 - BioRxiv
Insulin synthesis is sustained by Tent5 poly(A) polymerases
Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe health complications in humans. It is therefore essential to understand how beta cells control insulin synthesis and secretion, including the transcription, translation and decay of its messenger RNA. Using sequencing-based poly(A) tail length […]
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06/2026 - BioRxiv
Genomic codes governing enhancer RNA fate
Long-read sequencing has transformed transcriptome profiling, yet capturing full-length, non-polyadenylated transcripts like enhancer RNAs (eRNAs) remains challenging. Here, we introduce CFC-seq, combining cap-trapping and in vitro poly(A)-tailing to sequence poly(A) and non-poly(A) RNAs with precise transcription start site. Paired with our assembler, SALA, we identified 39,425 novel transcriptional units, including ∼24,000 eRNAs. Our data reveal […]