Genomics

Soskic Group

The Soskic Group focuses on the molecular, cellular, and genetic mechanisms underlying immune effector functions, with a particular emphasis on B cell biology and antibody divesrification. We aim to understand how gene regulatory networks control B cell differentiation and activation, how antibody class switching decisions are made, and how genetic variation shapes these processes to influence immune responses and susceptibility to autoimmunity.

Our Group takes a strongly interdisciplinary approach, integrating experimental and computational methods across immunology, genomics, and cell biology. We combine advanced immunological assays with high-throughput genomic technologies and computational analyses to dissect the molecular regulation of B cell activation and antibody diversification. In parallel, we investigate how genetic variation and dysregulated B cell activation contribute to immune disease risk.

For informal enquiries, please contact [email protected]

Group members

Publications

  • 07/2015 - PLOS One

    Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

    The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice. However, little is known regarding factors that regulate CTLA-4 expression and their effect upon its function to remove CD80 […]

    Read more
  • 08/2014 - Advances in Immunology

    Chapter Four – A Transendocytosis Perspective on the CD28/CTLA-4 Pathway

    T cell activation is a key event in the adaptive immune response and vital to the generation of both cellular and humoral immunity. Activation is required not only for effective CD4 T cell responses but also to provide help for B cells and the generation of cytotoxic T cell responses. Unsurprisingly, impaired T cell activation results in infectious pathology, whereas dysregulated activation can result in […]

    Read more
Page 1…Page 3Page 4Page 5