Single-cell ATAC sequencing with the 10X Genomics platform involves profiling the chromatin accessibility of individual cells/nuclei at a high resolution. The assay, commonly known as scATAC-seq (Single-cell Assay for Transposase-Accessible Chromatin sequencing), utilizes the 10X Genomics Chromium system to barcode and index individual nuclei, it provides valuable insights into the epigenomic landscape of individual cells, allowing researchers to study cellular heterogeneity and regulatory processes at high resolution.