Genomics

HEAD - Functional Genomics: Piero Carninci HEAD - Population & Medical Genomics: Nicole Soranzo

The Research Centre for Genomics will pursue research aimed at uncovering the complex mechanisms governing gene expression and how heritable genetic information translates into phenotypic traits.

Applied to humans, and in the context of precision medicine, this type of research can identify molecular targets and markers for disease prevention, early detection, and personalised treatment. In addition to carrying out genetic and genomic studies with a focus on (but not limited to) disease-associated mechanisms, the Centre for Genomics will promote and help implement large-scale genomic screening projects for patient stratification.

The Research Centre for Genomics will be composed of two complementary research programmes in Population and Medical Genomics (i.e. the use of genomic information to pinpoint the genetic causes of specific defects) and in Functional Genomics (i.e. the development and use of new methods to study the relation between the individual genome and biological function).

Centre members

Research groups

  • Calviello Group

    The Calviello Group is a new multidisciplinary research group in the Genomics Research Centre – Functional Genomics Programme, adjunct with the Computational Biology Research Centre starting from September 2021. The group studies post-transcriptional gene regulation, employing computational and experimental methods revolving around the -omics of translation, a fundamental process which dictates the functions of transcribed […]

  • Carninci Group

    The Carninci Group strive to develop and broadly use technologies to comprehensively study the non-protein-coding part of the genome, its function and interactome.

  • Soranzo Group

  • Soskic Group

    Immune-mediated diseases are chronic and disabling conditions affecting large number of people. Genome wide association studies (GWAS) have mapped hundreds of risk loci associated with immune-mediated diseases, opening up a tremendous potential to discover disease mechanisms and identify new drug targets. However, disease variants are difficult to study as they are often in non-coding regions […]