Genomics

HEAD - Functional Genomics: Piero Carninci HEAD - Population & Medical Genomics: Nicole Soranzo

The Research Centre for Genomics will pursue research aimed at uncovering the complex mechanisms governing gene expression and how heritable genetic information translates into phenotypic traits.

Applied to humans, and in the context of precision medicine, this type of research can identify molecular targets and markers for disease prevention, early detection, and personalised treatment. In addition to carrying out genetic and genomic studies with a focus on (but not limited to) disease-associated mechanisms, the Centre for Genomics will promote and help implement large-scale genomic screening projects for patient stratification.

The Research Centre for Genomics will be composed of two complementary research programmes in Population and Medical Genomics (i.e. the use of genomic information to pinpoint the genetic causes of specific defects) and in Functional Genomics (i.e. the development and use of new methods to study the relation between the individual genome and biological function).

Piero Carninci
HEAD - Functional Genomics
Nicole Soranzo Nicole Soranzo
HEAD - Population & Medical Genomics

Research groups

  • Bienko Group

    The Bienko Lab at HT aims at understanding the design principles and mechanisms that shape the spatial arrangement of DNA, RNAs and proteins in the nucleus of mammalian cells. We investigate how the three-dimensional (3D) architecture of the genome instructs and/or is instructed by fundamental processes including DNA replication, transcription, and repair. We are particularly […]

  • Calviello Group

    The Calviello Group is a new multidisciplinary research group in the Genomics Research Centre – Functional Genomics Programme, adjunct with the Computational Biology Research Centre starting from September 2021. The group studies post-transcriptional gene regulation, employing computational and experimental methods revolving around the -omics of translation, a fundamental process which dictates the functions of transcribed […]

  • Carninci Group

    The Carninci Group strive to develop and broadly use technologies to comprehensively study the non-protein-coding part of the genome, its function and interactome.

  • Domínguez Conde Group

    The Domínguez Conde Group is a newly established research team in the Medical & Population Genomics programme of the Genomics Centre. We aim to understand early-life human immunity and immune-mediated diseases in children using cutting-edge genomic and computational methods. Our group leverages the unprecedented power of single-cell multimodal technologies to identify cellular phenotypes associated with […]

  • Glastonbury Group

    The Glastonbury Group applies and develops machine learning methods to understand the genetic basis of a range of complex diseases. With the advent of population scale biobanking, rich data modalities are being collected on hundreds of thousands of individuals. One such data type is imaging data, a high dimensional and information rich modality for human […]

Centre members