National Facility for Genomics

The 4200 TapeStation system is an automated electrophoresis tool for DNA and RNA sample quality control. Fully automated sample processing enables the analysis of size, concentration, and integrity. It provides a complete solution for sample quality control within any NGS or Biobank workflow.

The Fragment Analyzer system utilizes automated parallel capillary electrophoresis to provide reliable and high sensitivity quality control (QC) for nucleic acids. Common QC bottlenecks are resolved by the automation of key steps such as gel loading and sample injection increasing lab efficiency.

The Femto Pulse system provides an automated pulsed-field capillary electrophoresis system that achieves 10 times higher sensitivity for smears and up to 100 times for fragments respect to standard one. The pulsed-field enables detecting nucleic acids into the lower femtogram range.

GloMax® Discover is a multimode plate reader that provides flexible use of filters and includes high-performance luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence capabilities. It can be integrated into high-throughput automated workflows.

Features:

• Reliable DNA, RNA and miRNA extraction from virtually any sample type
• Mid- to high-throughput solution with dedicated purification kits saves costs and time
• User-friendly software allows for easy data management and documentation
• Innovative design features increase safety and minimize cross-contamination
• Convenient, flexible and easy-to-use instrument with small footprint

The Agilent Bravo NGS workstation is built on the Bravo automated liquid handling robot preconfigured for library prep and enrichment when using next-generation sequencing (NGS) protocols. A simple and intuitive interface enables users to quickly set up and run pre-programmed protocols.

The E220 enables multi-sample, batch preparation, capable of processing a wide range of sample types and volumes. The E220 may be programmed to process from 1 to 96 samples in a single batch. For example, with 96 samples, 96 different AFA energies may be pre-programmed.

The Echo 525R Liquid Handler allows to transfer small, accurate, and precise amounts of samples and reagents to achieve miniaturized reaction volumes. The miniaturization of NGS library prep reduces reagents cost and the amount of sample input required, and at the same time increases throughput while providing high quality sequencing data.

The Biomek i7 Automated Workstation has been designed to optimize dependability and walk-away time in mid- to high-throughput labs. The Biomek i7 can be equipped with up to 45 deck positions, include both Multichannel and Span-8 pipette heads and is able to transfer volumes from 0.5 µL to 5,000 µL. It can be integrated with the Echo Liquid Handler for volume miniaturization.

NovaSeq 6000 System is the most powerful Illumina sequencer. It leverages sequencing by synthesis (SBS) technology to deliver accurate data and performance and it incorporates patterned dual flow cell technology to generate an unprecedented level of sequencing throughput (6000 Gb) and applications.

​​​​​​​The NextSeq 2000 System is a highly flexible and scalable benchtop system that generated up to 360 Gb per run. It supports a broad range of standard mid-throughput NGS methods such as exome sequencing, target enrichment, single-cell profiling and transcriptome sequencing as well as emerging techniques, including spatialomics. It allows a rapid, accurate, on-cloud or on-board data analysis.

PromethION 48 is a high-throughput Nanopore sequencing device using the single molecule sequencing technology and massively paralleled. It allows up to 48 sequencing experiments to be run concurrently or individually, delivering yields of up to 9,600 Gbases.

The Chromium Controller uses advanced microfluidics to perform single cell partitioning and barcoding in a matter of minutes. Powered by Next GEM technology, the Chromium Controller enables integrated analysis of single cells at massive scale allowing the discovery of gene expression dynamics and molecular profiling of individual cell types. Chromium Controller runs low- and standard-throughput assays.

Chromium X can analyse hundreds to hundreds of thousands of cells in a single run, making million cell studies routine and large-scale studies more affordable and practical. Chromium X is compatible with all 10x current single cell assays, including low-, standard- and high-throughput. With the high-throughput assay, it is possible to target up to 20,000 cells/nuclei per individual reaction or up to 60,000 cells/nuclei when using multiplex reagents.

​​​​​​​​​​​​​​The Chromium Connect is a system that combines proprietary 10x microfluidics technology using the Chromium Automated Controller with precise, automated liquid handling that allows users to run 10x Genomics end to end library construction workflow with minimal user interaction.

The benchtop Singulator System enables reproducible, rapid and hands-off dissociation of a wide range of tissues into single-cell or nuclei suspensions with walk-away operation. Suspensions of nuclei or high-viability cells can be obtained for a wide range of single-cell analyses. Its ability to perform cold dissociation minimizes the expression of stress-related genes in cells and helps preserve RNA quality in nuclei.

The BD Rhapsody™ Single-Cell Analysis System enables single-cell capture and barcoding of hundreds to thousands of single cells for analysis of genomic and proteomic information, using proprietary, gentle, robust microwell-based single-cell partitioning technology.

cellenONE® F1.4 is based on multi-fluorescence image-based single-cell sorting technologies and allows detection and imaging of fluorescent markers excited by up to 4 different light sources. It allows sorting and gentle dispensing of any biological active compounds and cells.

Visium Spatial Gene Expression is a next-generation molecular profiling solution for classifying tissue based on total mRNA. Map the whole transcriptome with morphological context in FFPE or fresh-frozen tissues to discover novel insights into normal development, disease pathology, and clinical translational research.

The GeoMx Digital Spatial Profiler (DSP) provides morphological context in spatial transcriptomics and spatial proteomics experiments from just one slide. From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial biology solution designed to conform to your ever-changing research needs.

The new Visium CytAssist is a compact, benchtop instrument that enables the transfer of transcriptomic probes from standard glass slides to Visium slides, enabling spatial profiling insights to be gained from even more samples. Compatible with hematoxylin and eosin (H&E)- or immunofluorescence (IF)-stained tissue sections, CytAssist allows pre-sectioned tissues to be used for the Visium workflow. You can further maximize your Visium experiments by screening tissue sections using standard histological techniques to find biologically significant sections and then precisely align those sections within the Visium slide Capture Area using CytAssist.