Human Technopole

The outcome of the public consultation conducted over the past months to identify the perceived priorities of the national life sciences community in terms of research infrastructure, as part of the broad scientific focus of Human Technopole (HT) has been published in the Final Report.   Thanks to the participation of the scientific and research community, […]

The international research project ‘NEUROCOV’ on the long-term neurological and psychiatric effects of COVID-19 has kicked off. The five-year EU-funded project was developed by Human Technopole and the German Centre for Neurodegenerative Diseases (DZNE) and involves ten institutes from seven countries. Human Technopole, which will receive EUR 3.2 Million European Commission funding, will be engaged […]

Differentiation of pluripotent stem cells (PSCs) has successfully been used to study tissue and organ development in vitro. Eleonora Conti and Oliver Harschnitz review the pros and cons of using human PSCs to investigate the development of placodes – embryonic structures giving rise to diverse organs – during the early steps of human embryonic development […]

Researchers at the Human Technopole and Max Planck Institute of Molecular Cell Biology and Genetics show how molecular cargo trains change direction in cellular micro-antennas. Cilia are antenna-like structures that protrude outwards from the surface of eukaryotic cells. Misassembled cilia in humans can cause numerous diseases from infertility to lung malfunction. The assembly and maintenance […]

Cilia are hair-like organelles that extend from most eukaryotic cells and perform many functions, including motility and signaling. Together with collaborators at the University of Geneva (Hamel-Guichard lab) and Biozentrum, University of Basel (Engel Lab), Dr. Gaia Pigino’s Group at the Human Technopole in Milan has now revealed that cilia have a specialised transport hub […]

Supervised classification methods can be used for the analysis of genetic screens obtained through the CRISPR-Cas9 genome editing technology. Nevertheless, these methods require large sets of reference genes to be included among those targeted with CRISPR. Alessandro Vinceti, of the Iorio Group, presents a novel computational method to identify reference gene sets of minimal size […]

Recombination of retrotransposons is known to affect genome stability and evolution, yet the significance of this process and its impact on the genome of human somatic cells are poorly understood. Giovanni Pascarella and Piero Carninci set up a new framework enabling comprehensive studies of retrotransposon recombination-driven genomic diversity in healthy and diseased tissues. The DNA […]

Our Associate Head of the Health Data Science Centre has been appointed to a new task force created by Lombardy Region which aims to reduce waiting lists and verify the proper management in the provision of health services to citizens. The task force includes members from Lombardy Region Welfare General Management, ATS, ASST, Lombardy Health […]

The works on display at the 23rd International Exhibition, “Unknown Unknowns. An Introduction to Mysteries”, also include two microscopy images created by Human Technopole researchers. The unknown, the mysterious, what we “know we don’t know”. This is the theme at the heart of the exhibition, curated by Ersilia Vaudo, astrophysicist and Chief Diversity Officer of […]

DNA double-strand breaks (DSBs) can cause mutations and genomic rearrangements resulting in genome instability thus contributing to the onset of genetic disorders and cancer. Magda Bienko and Nicola Crosetto provide tools and resources to investigate spontaneous DSBs that arise in an in vitro model of neurodevelopmental disorder pathogenesis. DNA damage can be either induced by […]