Highlights
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How APOE4 affects human brain in Alzheimer’s disease
Apolipoprotein E (APOE) is a small protein encoded by the APOE gene regulating lipid homeostasis in mammals. The e4 variant of the APOE gene (APOE4) is associated with an increased risk of developing Alzheimer’s disease (AD) in mammals. A Nature study co-authored by Jose Davila-Velderrain reveals cell-type specific effects of APOE4 on cholesterol metabolism and […]
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Exploring The ‘Dark Matter’ Of Colorectal Cancer
An international study co-ordinated by Andrea Sottoriva, Head of Human Technopole’s Computational Biology Research Centre, together with researchers from the Institute for Cancer Research (ICR) in London, reveals that key changes that explain mechanistic aspects of the onset and development of intestinal tumours come not only from genetic mutations, but also from so-called ‘epigenetics’ and […]
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Human Technopole Studies Neurological and Psychiatric Effects of Covid-19
The international research project ‘NEUROCOV’ on the long-term neurological and psychiatric effects of COVID-19 has kicked off. The five-year EU-funded project was developed by Human Technopole and the German Centre for Neurodegenerative Diseases (DZNE) and involves ten institutes from seven countries. Human Technopole, which will receive EUR 3.2 Million European Commission funding, will be engaged […]
Research at HT
Improving human health and well-being is the ultimate goal of Human Technopole. We need to prevent and cure diseases to allow people of all ages to not only live longer, but also live better.
Discover more about our:
Thanks to a global and interdisciplinary study of human biology, our research is aimed at understanding the mechanisms at the basis of various diseases, leveraging the technological advances of the last decade and the enormous amount of biological, clinical and socio-economic data currently available to improve our healthcare systems and our overall quality of life.
Human Technopole’s research is based on five interdisciplinary research centres: Genomics, Neurogenomics, Structural Biology, Computational Biology and Health Data Science. Research activity is supported by six state-of-the-art facilities.
External Trainings
BrainOmics
Category: Course
Location: In presence
Registration Deadline: 10/10/2022
Date: 28/11/2022 – 02/12/2022
HT Cryo-EM Symposium
Category: Workshop/Symposium
Location: In presence
Registration Deadline: 31/07/2022
Date: 29/09/2022 – 30/09/2022
Single-cell sequencing technologies & applications
Category: Workshop/Symposium
Location: Hybrid
Registration Deadline: 31/07/2022
Date: 13/09/2022 – 13/09/2022
Deep Learning for Microscopy Image Analysis 2022
Category: Course
Location: Online
Registration Deadline: 19/06/2022
Date: 18/07/2022 – 22/07/2022
Deep Learning for Microscopy Image Analysis 2021
Category: Course
Location: Online
Registration Deadline: 31/10/2021
Date: 22/11/2021 – 26/11/2021
Content-Aware Image Restoration (CARE) Workshop
Category: Workshop/Symposium
Location: Online
Registration Deadline: 12/04/2021
Date: 19/05/2021 – 21/05/2021
Work with us
We offer the opportunity to be part of a new, dynamic research institute promoting a highly collaborative and international working environment.
We aim to attract the best resources in each field with a selection based on merit and transparency as we believe that highly diverse teams produce the best and most innovative results.
If you are a passionate person who likes to seize great challenges, consider applying for one of our scientific or administrative vacancies.
Latest news
Introducing Ivano Legnini
Ivano Legnini is an Italian molecular and systems biologist interested in gene regulation. He currently lives in Berlin, working at the Max Delbrück Center – Berlin Institute for Medical Systems Biology, in the lab of Nikolaus Rajewsky. Ivano did his PhD in the lab of Irene Bozzoni at Sapienza University of Rome, where he also […]
How APOE4 affects human brain in Alzheimer’s disease
Apolipoprotein E (APOE) is a small protein encoded by the APOE gene regulating lipid homeostasis in mammals. The e4 variant of the APOE gene (APOE4) is associated with an increased risk of developing Alzheimer’s disease (AD) in mammals. A Nature study co-authored by Jose Davila-Velderrain reveals cell-type specific effects of APOE4 on cholesterol metabolism and […]
Measuring chromatin compaction with FRET-FISH
DNA intercalating dyes and massively sequencing techniques are traditionally used to study nuclear chromatin compaction. These tools, however, do not allow for direct measurement of chromatin compaction of individual loci. Nicola Crosetto and Magda Bienko combine fluorescence resonance energy transfer (FRET) with DNA fluorescence in situ hybridization (FISH) to assess the level of chromatin compaction […]
Exploring The ‘Dark Matter’ Of Colorectal Cancer
An international study co-ordinated by Andrea Sottoriva, Head of Human Technopole’s Computational Biology Research Centre, together with researchers from the Institute for Cancer Research (ICR) in London, reveals that key changes that explain mechanistic aspects of the onset and development of intestinal tumours come not only from genetic mutations, but also from so-called ‘epigenetics’ and […]
From risk to resilience in mental health and developmental diversity
World-leading interdisciplinary research groups have committed to provide innovative approaches to improve the quality of life of individuals with neurodevelopmental disorders Paris, 25th October 2022 The consortium of the EU-funded project Risk and Resilience in Developmental Diversity and Mental Health (R2D2-MH) is kicking-off today in Paris. 26 European and associated partners (Australia, Canada and Israel) […]
Bridging Artificial Intelligence and Machine Learning with bioimage analysis
The AI4Life project launched today, marks an exciting chapter in the computational and life science research communities. The €4 million Horizon Europe funded project aims to create accessible, harmonized, and interoperable AI tools and methods for solving today’s microscopy image analysis problems. The gap Machine learning (ML) has accelerated frontier research in the life sciences, […]
Message by President Verona and CdS
Milan, 24 September 2022 Dear Researchers on behalf of the Consiglio di Sorveglianza of the Foundation that I chair, I would like to confirm that I have received and read with great attention the letter addressed to us in recent days by hundreds of Italian researchers, in which they reaffirm the great interest that the […]
Neural Organoids & Co: when the name matters
Nervous system organoids are three-dimensional (3D) cellular models derived from human pluripotent stem cells that represent key tools to study the development of the human nervous system. In a perspective article published in Nature, Giuseppe Testa and colleagues critically review the origin, nomenclature, and classification of these popular neuronal 3D cellular models. Their work proposes […]
Urban Oasis at Human Technopole
The installation ‘Urban.Climate.Oasis Milano’, selected as part of the S+T+ARTS call promoted by the European Commission, was inaugurated today at Human Technopole: the waste heat produced by the Institute will feed a greenhouse for the cultivation of algae that will be used to study human biology. The work is by Markus Jeschaunig, an internationally renowned […]
Genome-wide association studies to understand immune diseases
Genetic variants are alternative versions of the DNA sequence that can sometimes be associated with the risk of developing a disease, including autoimmune disorders. Determining the causality between genetic variants and autoimmunity is difficult, due to technical limitations of existing mapping strategies. Blagoje Soskic and collaborators summarise how Genome-wide association studies (GWAS) have contributed to […]