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Single-cell multiome ATAC + Gene Expression is a cutting-edge technology that enables the simultaneous profiling of chromatin accessibility and gene expression at the single-cell level, providing a comprehensive view of the molecular landscape within individual cells. This technology is widely used in various biological research areas, including understanding cellular diversity in tissues, identifying cell types and states, deciphering regulatory networks, and gaining insights into how chromatin accessibility relates to gene expression at the single-cell level.

Single-cell immune profiling with 10x Genomics technology is a powerful method for 5’ RNA sequencing at the single-cell level and to profile at the same time the T-cells and/or B-cells receptors at single cell level by sequencing the V(D)J regions.

Single-cell ATAC sequencing with the 10X Genomics platform involves profiling the chromatin accessibility of individual cells/nuclei at a high resolution. The assay, commonly known as scATAC-seq (Single-cell Assay for Transposase-Accessible Chromatin sequencing), utilizes the 10X Genomics Chromium system to barcode and index individual nuclei, it provides valuable insights into the epigenomic landscape of individual cells, allowing researchers to study cellular heterogeneity and regulatory processes at high resolution.

Single-cell 3′ RNA sequencing with 10x Genomics technology is a powerful method for studying gene expression at the single-cell level. It enables the profiling of thousands to tens of thousands of single cells in parallel. It captures heterogeneity within cell populations, allowing the identification of rare cell types and subpopulations. It reveals differences in gene expression between individual cells, providing a more nuanced understanding of cellular diversity.

The Fixed RNA Profiling assay, also called the Single Cell Gene Expression Flex assay by 10X Genomics, is a way to prepare single cell RNA-seq libraries from formaldehyde-fixed cells and tissues as well as FFPE tissue blocks (please consider that from FFPE tissues the isolated population primarily consists of nuclei suspension, thus the RNA-seq analysis is to be intended at nuclear level). This process allows researchers to lock in the biological state of their samples at the time of fixation and store the fixed cell suspension for at least 6 months at -80°C.