High resolution, functional imaging based on high density MEA electronic interfaces measuring extracellular voltage potentials. The system available is the multichannel amplifier BioCAM DupleX and planar MEAs electronic chips equipped with 4,096 electrodes (3BRAIN AG, Pfäffikon SZ, Switzerland). The MEAs chip is the CorePlateTM 1W38/60 (NF55.004_MEA chip testing and provision) with a recording area of 3.8 mm x 3.8 mm, each electrode is 21 mm x 21 mm with a 60 mm pitch. The assay is suitable for the characterization of functional phenotypes in cell networks, and for compound screening. The high density of electrodes allows to collect a large amount of data within a single recording, and it is particularly suitable for accessing the electrical phenotype of brain and cardiac organoids.