This service comprises 8 hours of equipment time on the Orbitrap Astral LC-MS. The configuration of the system is: Vanquish NEO HPLC in trap and elute configuration. Mobile phase A is 0.1% formic acid in water, mobile phase B is 80% acetonitrile in water with 0.1% formic acid. The MS is set up with an EasySpray source. The MS is operated for high- throughput, with EasySpray pepMap columns (15cm, 150µm diameter, 10nm pore size). It is possible to use the FAIMS filter to improve sensitivity or fractionate samples online. Overhead on measurements due to sample loading and column washing is about 2 minutes per injection. Typical gradient length 15 minutes (no gains are typically observed beyond this gradient length due to the speed of the Astral analyser and the operation in high flow). This configuration allows for up to 100 samples per day. Both DIA and DDA proteomics workflows are available. The service does not comprise sample preparation from proteins to peptides.