Alice Giustacchini

Alice obtained her PhD from San Raffaele University under the supervision of Professor Luigi Naldini, with a project focusing on the role of microRNAs in the regulation of haematopoietic stem cell functions. She next moved to the UK to undertake a post-doc in the laboratories of Professor Sten Eirik Jacobsen and Adam Mead at the University of Oxford. During her post-doc she focused on the development of novel single-cell approaches to resolve cell heterogeneity in leukemic stem cells during therapy response. Since 2019, Alice is leading a research group at the University College London (UCL) Great Ormond Street Institute of Child Health and she has now joined the Human Technopole to set up a research group. Alice’s research revolves around understanding the biological mechanisms that make leukemia unresponsive to conventional therapies and identifying novel therapeutic targets allowing for their selective targeting. By combining single-cell genomics and proteomics with stem cell functional assays, her group aims to develop novel strategies to prevent and treat leukemia progression.

Contacts

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Publications

  • 06/2016 - Cancer Cell

    miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia

    MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible miRNA-126 cassette was switched off. Regression was accompanied by upregulation of cell-cycle regulators and B cell differentiation genes, and downregulation of oncogenic signaling pathways. Expression of […]

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