Nicolò Caporale

Publications

10/2021 - Frontiers in Cellular Neuroscience

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System

Myelin is the lipidic insulating structure enwrapping axons and allowing fast saltatory nerve conduction. In the central nervous system, myelin sheath is the result of the complex packaging of multilamellar extensions of oligodendrocyte (OL) membranes. Before reaching myelinating capabilities, OLs undergo a very precise program of differentiation and maturation that starts from OL precursor cells […]

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12/2020 - The EMBO Journal

COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids

COVID-19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS-CoV-2’s neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.

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11/2019 - Stem Cell Reports

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

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