Cardiometabolic Diseases

Cardiometabolic diseases – encompassing conditions like heart disease, stroke, and diabetes – collectively represent the leading causes of morbidity and mortality worldwide.

The Programme relies on the hypothesis that integrating genomic data with specific characteristics (or traits) of an individual can reveal significant insights into cardiometabolic diseases. It will combine molecular assays with multi-omic analysis of the “expressed genome” (e.g. RNA, proteins and metabolites), electronic health records and population and patient cohort studies to identify causal pathways for cardiometabolic diseases. These analyses will be complemented by targeted deep phenotyping of smaller groups of individuals to identify and validate novel therapeutic targets. Finally, HT researchers will develop risk assessment tools, strategies, and interventions to improve the prevention and management of cardiometabolic diseases in Italy and globally.