Neurodevelopmental and Neuropsychiatric Conditions (NPDs)

Neurodevelopmental (such as autism spectrum disorders) and neuropsychiatric disorders (NPDs, e.g. schizophrenia) are complex diseases originating from multiple genetic and environmental factors. HT researchers aim to investigate and dissect the fundamental mechanisms of these diseases across biological scales.

The overarching goal of this Programme is to improve our ability to diagnose, prevent and support the broad spectrum of neurodiverse individuals. This will be possible through the phenotyping of clinical cohorts as well as integrating cohort-derived clinical data with those from multi-omics analysis, stem cell reprogramming, brain organoids, and other in vitro and in vivo models. Such a systematic approach will be complemented by cutting-edge computational methods for analysing complex datasets.