Francesca Coscia

Francesca Coscia

• Research Group Leader, Coscia Group

EMAIL CONTACT: francesca.coscia[at]fht.org

Francesca Coscia is a structural biochemist and currently group leader at The Centre for Structural Biology. Her laboratory focuses on unravelling the structure and function of key macromolecules involved in thyroid hormone homeostasis, autoimmune diseases and cancer.

Short CV:

Since 2021 Group leader – Human Technopole

2017-2021 PostDoc – MRC Laboratory of Molecular Biology (Cambridge, UK)
Mentor: Prof. Jan Löwe

2014-2016 PostDoc – Birkbeck College (London, UK)
Mentor: Prof. Elena Orlova

2014 PhD in structural biology and nanobiology – Institut de Biologie Structurale (Grenoble, FR)
Nanoscience foundation international PhD fellowship
Mentors: Dr. Carlo Petosa, Dr. Guy Schoehn

2010 Summer internship – EMBL (Grenoble, FR)
Mentors: Dr. Stephen Cusack, Dr. Juan Reguera

2010 Research assistant – University Federico II (Naples, IT)
Mentor: Prof. Filomena Sica

2009 MSc Chemical Sciences – University Federico II (Naples, IT)
Summa cum laude
Mentors: Prof. Filomena Sica, Prof. Elio Pizzo

2007 BSc Chemistry – University Federico II (Naples, IT)
Summa cum laude
Mentor: Prof. Filomena Sica

Awards and funding:

2021 ERC starting grant
2021 International award “Gaetano Salvatore” for the thyroid physiopathology (Accademia Nazionale dei Lincei)
2021 European thyroid journal lecture award (from European thyroid association)
2020 Brenner PostDoc Prize – For outstanding research carried out at MRC-LMB
2019 MRC Special Award
2011-2014 Nanosciences foundation international PhD fellowship

Mentions:

Carrasco, Nature News&Views 2020
Diamond Light Source case studies 2020
First look at atomic structure of human thyroglobulin
The Structure of human thyroglobulin identified
Yearbook of Paediatric Endocrinology 2020 (p.21)
Interview to Coscia group at Superquark (Italian)

Full list of Publications

 

Selected publications:

Grassi, E. S.; Rurale, G.; de Filippis, T.; Gentilini, D.; Carbone, E.; Coscia, F.; Uraghi, S.; Bullock, M.; Clifton-Bligh, R.J.; Gupta, A. K.; Persani, L.; The length of FOXE1 polyalanine tract in congenital hypothyroidism: Evidence for a pathogenic role from familial, molecular and cohort studies. Frontiers in Endocrinology, 14. 2023. ISSN 1664-2392. https://doi.org/10.3389/fendo.2023.1127312

Mauri, A.; Duse, A.; Palm, G.; Previtali, R.; Bova, SM.; Olivotto, S.; Benedetti, S.; Coscia, F.; Veggiotti, P.; Cereda, C.; Molecular Genetics of GLUT1DS Italian Pediatric Cohort: 10 Novel Disease-Related Variants and Structural Analysis. Int J Mol Sci. 2022 Nov 4;23(21):13560. doi: 10.3390/ijms232113560.

Tosatto, L.; Coscia, F.; A glance at post-translational modifications of human thyroglobulin: potential impact on function and pathogenesis. European Thyroid Journal, 11 (3) 2022. https://doi.org/10.1530/ETJ-22-0046.

Rubio-Sánchez, R; O’Flaherty, D. K.; Wang, A.; Coscia, F.; Petris, G.; Di Michele, L.; Cicuta, P.; Bonfio, C.; Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells. Journal of the American Chemical Society, 2021, 143, 40, 16589–16598. https://doi.org/10.1021/jacs.1c06595.

Coscia, F.; Löwe, J.; Cryo-EM structure of the full-length Lon protease from Thermus thermophilus. FEBS Letters, 2021. https://doi.org/10.1002/1873-3468.14199.

Coscia, F.; Taler-Verčič, A.; Cryo-EM: A new dawn in thyroid biology. Molecular and Cellular Endocrinology, Volume 531, 2021, 111309, ISSN 0303-7207. https://doi.org/10.1016/j.mce.2021.111309.

Naydenova, K.; Muir, K. W.; Wu, L.-F.; Zhang, Z.; Coscia, F.; Peet, M. J.; Castro-Hartmann, P.; Qian, P.; Sader, K.; Dent, K.; Kimanius, D.; Sutherland, J. D.; Löwe, J.; Barford, D.; Russo, C. J. Structure of the SARS-CoV-2 RNA-Dependent RNA Polymerase in the Presence of Favipiravir-RTP. PNAS 2021, 118 (7). https://doi.org/10.1073/pnas.2021946118.

Coscia, F.; Taler-Verčič, A.; Chang, V. T.; Sinn, L.; O’Reilly, F. J.; Izoré, T.; Renko, M.; Berger, I.; Rappsilber, J.; Turk, D.; Löwe, J. The Structure of Human Thyroglobulin. Nature 2020, 578 (7796), 627–630. https://doi.org/10.1038/s41586-020-1995-4.

Reguera, J.; Gerlach, P.; Rosenthal, M.; Gaudon, S.; Coscia, F.; Günther, S.; Cusack, S. Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. PLOS Pathogens 2016, 12 (6), e1005636. https://doi.org/10.1371/journal.ppat.1005636.

Coscia, F.; Estrozi, L. F.; Hans, F.; Malet, H.; Noirclerc-Savoye, M.; Schoehn, G.; Petosa, C. Fusion to a Homo-Oligomeric Scaffold Allows Cryo-EM Analysis of a Small Protein. Scientific Reports 2016, 6 (1), 30909. https://doi.org/10.1038/srep30909.

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