Francesca Coscia

Francesca Coscia è una biochimica strutturale e attualmente capogruppo presso il Centro di Biologia Strutturale. Il suo laboratorio si concentra sullo svelamento della struttura e della funzione delle macromolecole chiave coinvolte nell’omeostasi degli ormoni tiroidei, nelle malattie autoimmuni e nel cancro.

Short CV:

Since 2021 Group leader – Human Technopole

2017-2021 PostDoc – MRC Laboratory of Molecular Biology (Cambridge, UK)
Mentor: Prof. Jan Löwe

2014-2016 PostDoc – Birkbeck College (London, UK)
Mentor: Prof. Elena Orlova

2014 PhD in structural biology and nanobiology – Institut de Biologie Structurale (Grenoble, FR)
Nanoscience foundation international PhD fellowship
Mentors: Dr. Carlo Petosa, Dr. Guy Schoehn

2010 Summer internship – EMBL (Grenoble, FR)
Mentors: Dr. Stephen Cusack, Dr. Juan Reguera

2010 Research assistant – University Federico II (Naples, IT)
Mentors: Prof. Filomena Sica

2009 MSc Chemical Sciences – University Federico II (Naples, IT)
Summa cum laude
Mentors: Prof. Filomena Sica, Prof. Elio Pizzo

2007 BSc Chemistry – University Federico II (Naples, IT)
Summa cum laude
Mentor: Filomena Sica

Fellowships and awards

2021 European thyroid journal lecture award (from European thyroid association)
2020 Brenner PostDoc Prize – For outstanding research carried out at MRC-LMB
2019 MRC Special Award
2011-2014 Nanosciences foundation international PhD fellowship

Mentions:

Carrasco, Nature News&Views 2020
Diamond Light Source case studies 2020
First look at atomic structure of human thyroglobulin
The Structure of human thyroglobulin identified
Yearbook of Paediatric Endocrinology 2020 (p.21)

Full list of Publications

 

Selected publications:

Coscia, F.; Taler-Verčič, A.; Cryo-EM: A new dawn in thyroid biology. Molecular and Cellular Endocrinology, Volume 531, 2021, 111309, ISSN 0303-7207. https://doi.org/10.1016/j.mce.2021.111309.

Naydenova, K.; Muir, K. W.; Wu, L.-F.; Zhang, Z.; Coscia, F.; Peet, M. J.; Castro-Hartmann, P.; Qian, P.; Sader, K.; Dent, K.; Kimanius, D.; Sutherland, J. D.; Löwe, J.; Barford, D.; Russo, C. J. Structure of the SARS-CoV-2 RNA-Dependent RNA Polymerase in the Presence of Favipiravir-RTP. PNAS 2021118 (7). https://doi.org/10.1073/pnas.2021946118.

Coscia, F.; Taler-Verčič, A.; Chang, V. T.; Sinn, L.; O’Reilly, F. J.; Izoré, T.; Renko, M.; Berger, I.; Rappsilber, J.; Turk, D.; Löwe, J. The Structure of Human Thyroglobulin. Nature 2020578 (7796), 627–630. https://doi.org/10.1038/s41586-020-1995-4.

Reguera, J.; Gerlach, P.; Rosenthal, M.; Gaudon, S.; Coscia, F.; Günther, S.; Cusack, S. Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. PLOS Pathogens 201612 (6), e1005636. https://doi.org/10.1371/journal.ppat.1005636.

Coscia, F.; Estrozi, L. F.; Hans, F.; Malet, H.; Noirclerc-Savoye, M.; Schoehn, G.; Petosa, C. Fusion to a Homo-Oligomeric Scaffold Allows Cryo-EM Analysis of a Small Protein. Scientific Reports 20166 (1), 30909. https://doi.org/10.1038/srep30909.

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