31 January 2025

Exploring Nuclear Proteomics with the PRUNE Project

Meet Carlos Jimenez, Postdoc in the Bienko Group (Genomics), who has been awarded a prestigious Marie Skłodowska-Curie Actions Postdoctoral Fellowship from the European Union. The grant, totalling €172,750.08 and covering a two-year period, will support his groundbreaking project PRUNE – Uncovering the Proteomic Radial Organisation within the Eukaryotic Nucleus – to study how the spatial arrangement of nuclear proteins contributes to optimal cell functioning.

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28 January 2025

The “tubulin code” in control of molecular train logistics in cilia

By developing a sophisticated in vitro system coupled with advanced imaging techniques and CRISPR genome editing, an international team of researchers from Human Technopole (Italy) and the TUD Dresden University of Technology (Germany) shows that tubulin tyrosination/detyrosination regulates the bidirectional IFT train movement and avoids collision between trains moving in opposite directions along the cilium. The research was funded by the ERC and the DFG “Physics of Life” Excellence Cluster. The results are published in Nature Communications.

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09 January 2025

How SNAPc recruits human RNA polymerases at snRNA genes

Using advanced cryo-electron microscopy and cross-linking mass spectrometry, HT researchers provide unprecedented insight into how SNAPc works as a “dual recruiter” for RNA Polymerase II and III. The findings are published in Nature Communications.

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