Researchers from Human Technopole, the Institute of Molecular Biotechnology and Bicocca University established a method for developing brain assembloids that allows reproducing salient aspects of the antero-posterior polarity of the human cerebral cortex in vitro and opens new possibilities for disease modelling. The study is published in Nature Methods.

An international collaboration between Human Technopole, Fudan University, the University of Edinburgh, and the SCALLOP Consortium identified hundreds of proteins in human plasma related to human behavioural traits and neuropsychiatric disorders. These proteins are potential targets for drug repurposing and novel therapeutic interventions for mental disorders. The findings are published in Nature Human Behaviour.

Using diverse omics approaches and multiscale disease modelling, Human Technopole researchers uncovered the effects of 7q11.23 CNV, a section of chromosome 7  on neuronal differentiation, gene expression, protein synthesis, and intrinsic neuronal excitability in two neurodevelopmental disorders (i.e., Williams-Beuren and 7q microduplication syndromes). The research results are published in The Journal of Clinical Investigation.