New results for our scientists
December was a busy month for our scientists.
After the publication of his latest work on Sciences Advances, Giuseppe Testa – Head of the Center for Neurogenomics – flew to the United States. Here he attended the Cold Spring Harbor Lab meeting on “the Development & 3D Modeling of the Human Brain” – the most important event on cerebral organs – and presented the research that will carry out in Human Technopole in this field.
The latest work led by Francesco Iorio – Group Leader of the Centre for Computational Biology – has been published in Nature Communications. The study demonstrates the consistency between large functional genomics datasets generated at the Wellcome Sanger Institute and the Broad Institute with CRISPR-Cas9 technology, paves the way for their possible integration and lays the basis for the creation of a map of all genetic dependencies of cancer.
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How SNAPc recruits human RNA polymerases at snRNA genes
Using advanced cryo-electron microscopy and cross-linking mass spectrometry, HT researchers provide unprecedented insight into how SNAPc works as a “dual recruiter” for RNA Polymerase II and III. The findings are published in Nature Communications.
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Italy at the centre of the Genome of Europe project
The Human Technopole, ELIXIR Italia, the national node of the European life sciences research infrastructure coordinated by the National Research Council (CNR), and the Centro Cardiologico Monzino, as the Italian coordinating centre, have been selected as the Italian partners of Genome of Europe (GoE), the largest EU-funded genomic project, whose ultimate goal is to make […]
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Human Technopole wins 2024 Oscar di Bilancio
On Friday 13 December, at Palazzo Mezzanotte in Milan, the Human Technopole Foundation’s ‘Integrated Report 2023’ received the Oscar di Bilancio in the social enterprises and non-profit organisations category. The award was presented to President Gianmario Verona, Elena Trovesi, Head of Administration, as well as the project leaders Giovanni Selmi, Head of Finance, and Alessandro […]
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Mosaic Organoids to Study the Brains of Multiple Patients Simultaneously
An international team of scientists from Human Technopole and the University of Milan has developed and validated an innovative approach to studying human brain development across multiple individuals simultaneously using single organoids—laboratory models that replicate key cellular processes of human neurodevelopment. The research paves the way for in vitro population studies. Additionally, the scientists have developed a novel computational method to more accurately quantify the genetic identity of individual cells profiled from multiple individuals concurrently. The findings have been published in Nature Methods.
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Cancer stem cell morphology predicts glioblastoma growth and resistance
Human Technopole researchers have identified adducin-γ (ADD3) as a crucial regulator of glioblastoma cancer stem cell morphology and intercellular bridges between tumour cells. These connections facilitate communication and allow tumour cells to share resources, evade chemotherapy, and survive in challenging conditions. The study has been funded by AIRC and the findings are published in Life Science Alliance.