New results for our scientists
December was a busy month for our scientists.
After the publication of his latest work on Sciences Advances, Giuseppe Testa – Head of the Center for Neurogenomics – flew to the United States. Here he attended the Cold Spring Harbor Lab meeting on “the Development & 3D Modeling of the Human Brain” – the most important event on cerebral organs – and presented the research that will carry out in Human Technopole in this field.
The latest work led by Francesco Iorio – Group Leader of the Centre for Computational Biology – has been published in Nature Communications. The study demonstrates the consistency between large functional genomics datasets generated at the Wellcome Sanger Institute and the Broad Institute with CRISPR-Cas9 technology, paves the way for their possible integration and lays the basis for the creation of a map of all genetic dependencies of cancer.
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Childhood Cancer: Free DNA in Blood Reveals Therapy Resistance
An international study coordinated by Milan’s Human Technopole, the Institute of Cancer Research (ICR) in London, and the Royal Marsden Hospital in London has shown that certain DNA fragments found in the blood of paediatric cancer patients can be used as “biomarkers” to obtain information on the characteristics of the disease and its ability to resist therapies. Analysing these fragments could represent an effective alternative to tumour tissue biopsy, a practice that is particularly difficult in children.
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Human Technopole at the Quirinale: Advancing Innovation with MIND
Human Technopole is honoured to have participated in today’s meeting at the Quirinale, where President of the Republic Sergio Mattarella welcomed a delegation from MIND on the occasion of the tenth anniversary of the universal exposition Milano EXPO 2015.
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Exploring Nuclear Proteomics with the PRUNE Project
Meet Carlos Jimenez, Postdoc in the Bienko Group (Genomics), who has been awarded a prestigious Marie Skłodowska-Curie Actions Postdoctoral Fellowship from the European Union. The grant, totalling €172,750.08 and covering a two-year period, will support his groundbreaking project PRUNE – Uncovering the Proteomic Radial Organisation within the Eukaryotic Nucleus – to study how the spatial arrangement of nuclear proteins contributes to optimal cell functioning.
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The “tubulin code” in control of molecular train logistics in cilia
By developing a sophisticated in vitro system coupled with advanced imaging techniques and CRISPR genome editing, an international team of researchers from Human Technopole (Italy) and the TUD Dresden University of Technology (Germany) shows that tubulin tyrosination/detyrosination regulates the bidirectional IFT train movement and avoids collision between trains moving in opposite directions along the cilium. The research was funded by the ERC and the DFG “Physics of Life” Excellence Cluster. The results are published in Nature Communications.
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Public Notice for HT’s list of lawyers online
The public notice for the creation of a list of lawyers, from which legal representation assignments may be drawn in the interest of the Human Technopole Foundation, is now online.