04 January 2023

CRISPRcleanR WebApp makes your life easier with CRISPR-Cas9 screens

A web-based application developed by the Iorio Group and the IT & digitalisation team at Human Technopole helps non-computational scientists process and analyse CRISPR-Cas9 screens by reducing false-positive hits. CRISPR/Cas9 technology has become the gold standard for genome and epigenome editing, for studying the regulation of gene expression, and for high-throughput screenings aiming at identifying […]

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22 December 2022

The second edition of our Integrated Report

The second edition of our Integrated Report covering the year 2021, is now online.  The Report is an important tool through which Human Technopole communicates its commitment to social responsibility, based on transparent, accurate and complete information. Our hope is that this can help promote trust towards the work carried out by Human Technopole and […]

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19 December 2022

OPEN HT: a dialogue with the scientific community

Today Monday 19 December from 10.00 a.m. in the Human Technopole Auditorium at MIND Milano Innovation District OPEN HT took place. The event represented an opportunity for dialogue between the life sciences Institute and the national scientific community. The initiative was also the occasion to share the developments of Human Technopole as detailed in the […]

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25 November 2022

Introducing Ivano Legnini

Ivano Legnini is an Italian molecular and systems biologist interested in gene regulation. He currently lives in Berlin, working at the Max Delbrück Center – Berlin Institute for Medical Systems Biology, in the lab of Nikolaus Rajewsky. Ivano did his PhD in the lab of Irene Bozzoni at Sapienza University of Rome, where he also […]

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16 November 2022

How APOE4 affects human brain in Alzheimer’s disease

Apolipoprotein E (APOE) is a small protein encoded by the APOE gene regulating lipid homeostasis in mammals.  The e4 variant of the APOE gene (APOE4) is associated with an increased risk of developing Alzheimer’s disease (AD) in mammals. A Nature study co-authored by Jose Davila-Velderrain reveals cell-type specific effects of APOE4 on cholesterol metabolism and […]

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