Mechanism of ciliary train switch and cargo recognition
A study by the Pigino Group at Human Technopole reveals that the conversion from anterograde to retrograde intraflagellar transport requires the complete disassembly of anterograde trains at the ciliary tip and provides the mechanisms for direction-specific cargo binding and transport in cilia.
The National Facility for Structural Biology with Paolo Swuec
Meet Paolo Swuec, responsible for running the Italy’s first Cryo-EM Facility and, today, Head of the National Facility for Structural Biology at Human Technopole: a hub for cutting-edge research, facilitating the structural characterization of biological entities, ranging from tissues to amino acid side-chains.
Chan Zuckerberg Initiative grant to the Glastonbury Group
The Glastonbury Group is among the recipients of the Data Insights Cycle 3 awards. The aim of the grant is to develop a machine learning model that identifies disease-relevant cell subpopulations whilst predicting a phenotype/disease of interest from large-scale single-cell RNA-seq data.
Understanding the pathogenesis of SARS-CoV-2 encephalitis
In collaboration with an international team of scientists, HT researchers identified a missense mutation in a gene involved in brain-intrinsic immunity as the genetic cause of SARS-CoV-2 brainstem encephalitis.
Machine learning reveals hidden features in histology images
Researchers at Human Technopole developed a self-supervised machine learning model that combines histology, gene expression, and genetic variation to automatically identify and cluster distinct tissue substructures, cells, and pathological features in human tissues.