Alessandro Vinceti
- Postdoc, Iorio Group
Alessandro Vinceti is a PhD student in the Computational Biology Research Centre at Human Technopole. He completed a Bachelor’s in Biotechnology from the University of Modena and Reggio Emilia, followed by a Master’s in Bioinformatics from the University of Bologna.
As part of his PhD, Alessandro is contributing to the development of tools for the correction and analysis of data derived from CRISPR-Cas9 screens based on large cohorts of human immortalised cancer cell lines. The aim is to exploit the genetic features of tumour models to find suitable therapeutic targets that will lead to the development/repurposing of the right drug for the right patient, following precision medicine principles.
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Publications
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11/2021 - BMC Genomics
CoRe: a robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens
Background CRISPR-Cas9 genome-wide screens are being increasingly performed, allowing systematic explorations of cancer dependencies at unprecedented accuracy and scale. One of the major computational challenges when analysing data derived from such screens is to identify genes that are essential for cell survival invariantly across tissues, conditions, and genomic-contexts (core-fitness genes), and to distinguish them from […]
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01/2021 - Genome Biology
Minimal genome-wide human CRISPR-Cas9 library
CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function datasets, resulting in a greater than 42% reduction in size compared to other CRISPR-Cas9 libraries while […]
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