Alessandro Vinceti

Alessandro Vinceti

Publications

  • 01/2021 - Genome Biology

    Minimal genome-wide human CRISPR-Cas9 library

    CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function datasets, resulting in a greater than 42% reduction in size compared to other CRISPR-Cas9 libraries while […]