Alice Giustacchini
- Research Group Leader, Giustacchini Group
Alice obtained her PhD from San Raffaele University under the supervision of Professor Luigi Naldini, with a project focusing on the role of microRNAs in the regulation of haematopoietic stem cell functions. She next moved to the UK to undertake a post-doc in the laboratories of Professor Sten Eirik Jacobsen and Adam Mead at the University of Oxford. During her post-doc she focused on the development of novel single-cell approaches to resolve cell heterogeneity in leukemic stem cells during therapy response. Since 2019, Alice is leading a research group at the University College London (UCL) Great Ormond Street Institute of Child Health and she has now joined the Human Technopole to set up a research group. Alice’s research revolves around understanding the biological mechanisms that make leukemia unresponsive to conventional therapies and identifying novel therapeutic targets allowing for their selective targeting. By combining single-cell genomics and proteomics with stem cell functional assays, her group aims to develop novel strategies to prevent and treat leukemia progression.
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Publications
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09/2023 - Nature Communications
Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner
Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to different challenges. However, feedback mechanisms by which HSCs, through their niches, sense acute losses of specific blood cell lineages remain to be established. While all […]