
Carlos Fernandez
- Head of ICT & Digitisation, ICT & Digitalisation
Publications
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01/2023 - Cell Reports Methods
An interactive web application for processing, correcting, and visualizing genome-wide pooled CRISPR-Cas9 screens
A limitation of pooled CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes arising from copy-number-amplified genomics regions. To solve this issue, we previously developed CRISPRcleanR: a computational method implemented as R/python package and in a dockerized version. CRISPRcleanR detects and corrects biased responses to CRISPR-Cas9 targeting in an unsupervised fashion, accurately reducing […]