Giuseppe Testa

Giuseppe Testa

  • Head of Neurogenomics
  • Research Group Leader, Testa Group

Giuseppe Testa, MD, PHD, MA, is a professor of Molecular Biology at Milan’s Università Statale and Director of the High Definition Disease Modelling Lab: Stem Cell and Organoid Epigenetics at the European Institute of Oncology. At Human Technopole, Prof. Testa leads the Neurogenomics centre of the research programme in collaboration with the Università Statale in Milan. The programme studies the molecular mechanisms underlying intellectual disabilities and autism.

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  • 05/2022 - Frontiers in Neuroscience

    EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation

    The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and neurodevelopmental disorders, particularly with respect to the malfunction of sits catalytic subunit EZH2. Here, we investigated the role of the EZH2-mediated H3K27me3 apposition in […]

  • 04/2022 - BioRxiv

    Benchmarking brain organoid recapitulation of fetal corticogenesis

    Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in vitro recapitulation of key features of human brain development affords the unique opportunity of investigating the developmental antecedents of neuropsychiatric conditions in the context of the actual patients’ genetic backgrounds. Specifically, multiple strategies of brain organoid (BO) differentiation have […]

  • 04/2022 - Cell Reports

    CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories

    Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly, implicating cortical abnormalities, how CHD8 haploinsufficiency affects neurodevelopmental is unclear. Here, employing human cerebral organoids, we find that CHD8 haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yields, at days 60 […]

  • 03/2022 - International Journal of Molecular Sciences

    The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

    Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill […]