Giuseppe Testa

Giuseppe Testa

Giuseppe Testa, MD, PHD, MA, is a professor of Molecular Biology at Milan’s Università Statale and Director of the Epigenetic Laboratory of Stem Cells at the European Institute of Oncology. At Human Technopole he heads the Centre for Neurogenomics, within which his lab studies the mechanisms of intellectual disability and autism.

Publications

  • 04/2021 - Nature Communications

    Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

    Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de novo chromatin state discovery on a library of different patient-derived organoids. By exploring this resource, we unveil a tumor-specific deregulated enhancerome that is cancer cell-intrinsic and […]

  • 02/2021 - Wiley

    Rethinking Human Embryo Research Policies

    It now seems technically feasible to culture human embryos beyond the “fourteen‐day limit,” which has the potential to increase scientific understanding of human development and perhaps improve infertility treatments. The fourteen‐day limit was adopted as a compromise but subsequently has been considered an ethical line. Does it remain relevant in light of technological advances permitting […]

  • 01/2021 - EMBO Reports

    Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation

    Transition from proliferative‐to‐invasive phenotypes promotes metastasis and therapy resistance in melanoma. Reversion of the invasive phenotype, however, is challenged by the poor understanding of mechanisms underlying its maintenance. Here, we report that the lncRNA TINCR is down‐regulated in metastatic melanoma and its silencing increases the expression levels of invasive markers, in vitro migration, in vivo tumor growth, and resistance […]

  • 01/2021 - Wiley

    Seizure activity and brain damage in a model of focal non‐convulsive status epilepticus

    Aims Focal non‐convulsive status epilepticus (FncSE) is a common emergency condition that may present as the first epileptic manifestation. In recent years, it has become increasingly clear that de novo FncSE should be promptly treated to improve post‐status outcome. Whether seizure activity occurring during the course of the FncSE contributes to ensuing brain damage has not been demonstrated unequivocally […]

  • 12/2020 - Nature Communications

    Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

    The thymus is a primary lymphoid organ, essential for T cell maturation and selection. There has been long-standing interest in processes underpinning thymus generation and the potential to manipulate it clinically, because alterations of thymus development or function can result in severe immunodeficiency and autoimmunity. Here, we identify epithelial-mesenchymal hybrid cells, capable of long-term expansion […]