Linda Masante

I am a Postdoc at the Genomics Research Centre – Functional Genomics Programme of Human Technopole. I hold a Ph.D. in Biomolecular Sciences from CIBIO, University of Trento.

I graduated in Molecular Biotechnology at the University of Turin in 2017. I focused on the role of Fgf14 protein in psychiatric disorders in the Laboratory of Neurophysiology of Neurodegenerative Diseases of Filippo Tempia.

I then moved to Trento for my Ph.D becoming part of the Giovanni Armenise-Harvard laboratory of Axonal Neurobiology led by Marie-Laure Baudet. There, I started to be passionate about RNA. In particular, I focused on a very peculiar type of RNAs, named circular RNAs, investigating how they translocate to the axonal compartment. During my Ph.D. I had the opportunity to join the GeneCore Facility headed by Vladimir Benes at EMBL, Heidelberg, to learn RNA-seq library preparation.

My current research is devoted to RNA metabolism in cortical neurons. I am interested in particular on the role of CPEB proteins in the regulation of RNA metabolism – from synthesis to decay – in basal condition and upon neuronal activation.

Publications

  • 07/2026 - BioRxiv

    Insulin synthesis is sustained by Tent5 poly(A) polymerases

    Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe health complications in humans. It is therefore essential to understand how beta cells control insulin synthesis and secretion, including the transcription, translation and decay of its messenger RNA. Using sequencing-based poly(A) tail length […]

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