Philipp Sebastian Erdmann
- Research Group Leader, Erdmann Group
Philipp Erdmann is a chemical biologist and microscopist. After five years as a project group leader at the MPI for Biochemistry, Martinsried, he joined HT in February 2021.
Philipp’s lab will focus on the analysis of liquid-liquid phase separation (LLPS) effects using in situ cryo-electron tomography. LLPS is often involved in crucial processes of both transmittable and non-transmittable human diseases, including virus infections and neurodegenerative disorders.
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Publications
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09/2024 - Nature Methods
Serialized on-grid lift-in sectioning for tomography (SOLIST) enables a biopsy at the nanoscale
Cryo-focused ion beam milling has substantially advanced our understanding of molecular processes by opening windows into cells. However, applying this technique to complex samples, such as tissues, has presented considerable technical challenges. Here we introduce an innovative adaptation of the cryo-lift-out technique, serialized on-grid lift-in sectioning for tomography (SOLIST), addressing these limitations. SOLIST enhances throughput, […]
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07/2022 - Science
In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains
The cilium is an antenna-like organelle that performs numerous cellular functions, including motility, sensing, and signaling. The base of the cilium contains a selective barrier that regulates the entry of large intraflagellar transport (IFT) trains, which carry cargo proteins required for ciliary assembly and maintenance. However, the native architecture of the ciliary base and the […]