Pietro Demela
- PhD Student, Soskic Group
Publications
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04/2026 - Mol Syst Biol
Competing gene regulatory networks drive naive and memory B cell differentiation
Elucidating the gene regulatory networks (GRNs) that control human B cell differentiation is crucial for understanding immune responses to infection, vaccination, and autoimmunity. Here, we map the GRNs guiding naive and memory B cell differentiation. Early in activation, both cell types engage highly similar GRNs. However, at later stages, naive B cells diverge into two […]
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05/2023 - Nature Communications
Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways
Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci associated with immune-mediated diseases. To assess the extent of the genetic sharing across nine immune-mediated diseases we apply genomic structural equation modelling to GWAS data from European populations. We identify three disease groups: gastrointestinal tract diseases, rheumatic and systemic diseases, and allergic diseases. Although loci […]