04/2021 - Antisense RNAs during early vertebrate development are divided in groups with distinct features

Long noncoding RNAs or lncRNAs are a class of non-protein-coding RNAs that are >200 nucleotides in length. Almost 50% of lncRNAs during zebrafish development are transcribed in an antisense direction to a protein-coding gene. However, the role of these Natural Antisense Transcripts or NATs during development remains enigmatic. To understand NATs in early vertebrate development, […]

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03/2021 - Integrated cross-study datasets of genetic dependencies in cancer

CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across large panels of cell lines to identify new therapeutic targets for precision cancer therapy. Integrating the datasets resulting from these studies is necessary to adequately represent the heterogeneity of human cancers and to assemble a comprehensive map of cancer genetic vulnerabilities. Here, we integrated […]

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02/2021 - Rethinking Human Embryo Research Policies

It now seems technically feasible to culture human embryos beyond the “fourteen‐day limit,” which has the potential to increase scientific understanding of human development and perhaps improve infertility treatments. The fourteen‐day limit was adopted as a compromise but subsequently has been considered an ethical line. Does it remain relevant in light of technological advances permitting […]

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