09/2021 - A small nucleosome from a weird virus with a fat genome
Valencia-Sánchez et al. (2021) and Liu et al. (2021) provide structural and biological insights about the existence and importance of a nucleosome-like particle in a family of giant viruses.
08/2021 - Social and material vulnerability in the face of seismic hazard: An analysis of the Italian case
The assessment of the vulnerability of a community endangerd by seismic hazard is of paramount importance for planning a precision policy aimed at the prevention and reduction of its seismic risk. We aim at measuring the vulnerability of the Italian municipalities exposed to seismic hazard, by analysing the open data offered by the Mappa dei […]
08/2021 - In vivo imaging shows continued association of several IFT A, B and dynein complexes while IFT trains U-turn at the tip
Flagellar assembly depends on intraflagellar transport (IFT), a bidirectional motility of protein carriers, the IFT trains. The trains are periodic assemblies of IFT-A and IFT-B subcomplexes and the motors kinesin-2 and IFT dynein. At the tip, anterograde trains are remodeled for retrograde IFT, a process that in Chlamydomonas involves kinesin-2 release and train fragmentation. However, […]
08/2021 - Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization
DNA loop extrusion by condensins and decatenation by DNA topoisomerase II (topo II) are thought to drive mitotic chromosome compaction and individualization. Here, we reveal that the linker histone H1.8 antagonizes condensins and topo II to shape mitotic chromosome organization. In vitro chromatin reconstitution experiments demonstrate that H1.8 inhibits binding of condensins and topo II […]
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