06/2019 - Better to stay apart: asset commonality, bipartite network centrality, and investment strategies
By exploiting a bipartite network representation of the relationships between mutual funds and portfolio holdings, we propose an indicator that we derive from the analysis of the network, labelled the Average Commonality Coefficient (ACC), which measures how frequently the assets in the fund portfolio are present in the portfolios of the other funds of the […]
06/2019 - Yeast membraneless compartments revealed by correlative light microscopy and electron tomography
Yeast essential enzymes are able to assemble and form membrane-less compartments in the cytoplasm during stress conditions (Narayanaswamy et al., 2009). These microcompartments form rapidly under ATP-depletion upon cellular regulation of pH and molecular crowding (Munder et al., 2016). So far, the behavior of most of these enzymes has been characterized by live imaging using fluorescence […]
05/2019 - In situ cryo-electron tomography and subtomogram averaging of intraflagellar transport trains
In situ cryo-electron tomography (cryo-ET) and subtomogram averaging are powerful tools, able to provide 3D structures of biological samples at sub-nanometer resolution, while preserving information about cellular context and higher-order assembly. Best results are typically achieved, when applied to highly repetitive structures, such as viruses. Other typical examples are protein complexes that decorate long stretches along ciliary microtubules at […]