Publications

Sequential profiling of plasma cell-free DNA (cfDNA) holds immense promise for early detection of patient progression. However, how to exploit the predictive power of cfDNA as a liquid biopsy in the clinic remains unclear. RAS pathway aberrations can be tracked in cfDNA to monitor resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer. […]

Recurrent successions of genomic changes, both within and between patients, reflect repeated evolutionary processes that are valuable for the anticipation of cancer progression. Multi-region sequencing allows the temporal order of some genomic changes in a tumor to be inferred, but the robust identification of repeated evolution across patients remains a challenge. We developed a machine-learning […]

Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western countries. Some HSE children carry inborn errors of the Toll-like receptor 3 (TLR3)-dependent IFN-α/β– and -λ–inducing pathway. Induced pluripotent stem cell (iPSC)-derived cortical neurons with TLR3 pathway mutations are highly susceptible to HSV-1, due to impairment of cell-intrinsic […]

Scientific production is steadily growing, exhibiting 4% annual growth in publications and 1.8% annual growth in the number of references per publication, together producing a 12-year doubling period in the total supply of references, i.e. links in the science citation network. This growth has far-reaching implications for how academic knowledge is connected, accessed and evaluated. […]

The Basel Committee on Banking Supervision has proposed a methodology to identify Systemically Important Financial Institutions based on a series of indicators that should account for the externalities that these institutions place into the system. In this article we argue that the methodology chosen by Basel III maintains the micro-prudential focus of Basel I and […]