04/2005 - Fine structure of the midgut and Malpighian papillae in Campodea (Monocampa) quilisi Silvestri, 1932 (Hexapoda, Diplura) with special reference to the metal composition and physiological significance of midgut intracellular electron-dense granules
The fine structure of the midgut and the Malpighian papillae in Campodea (Monocampa) quilisi Silvestri, 1932 (Hexapoda, Diplura) specimens was described. We observed the presence of electron-dense granules (EDGs) in the midgut epithelial cells, similar in genesis, structure and aspect to the type A spherocrystals described in the midgut epithelium of Collembola and Diplopoda. Energy-dispersive […]
12/2004 - Soil communities (Acari Oribatida; Hexapoda Collembola) in a clay pigeon shooting range
Clay pigeon shooting ranges can be an important source of heavy metal contamination in terrestrial ecosystems. The pellets contained in spent ammunition are mainly composed of lead (Pb) and antimony (Sb). Total concentrations of these metals were measured in soils from seven sampling sites within a clay pigeon shooting range and compared with two controls to investigate the […]
10/2004 - Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress response. These processes often are altered in tumors, and HDAC inhibitors have had pronounced antitumor activity with promising results in clinical trials. Here, we report the crystal structure of human HDAC8 in complex with a hydroxamic […]
06/2004 - Crystal structure of the quorum-sensing protein TraM and its interaction with the transcriptional regulator TraR
Transfer of the tumor-inducing plasmid in Agrobacterium tumefaciens is controlled by a quorum-sensing system whose main components are the transcriptional regulator TraR and its autoinducer. This system allows bacteria to synchronize infection of the host plant when a “quorum” of cells has been reached. TraM is an A. tumefaciens protein involved in the regulation of […]
02/2004 - Mechanism of activation of human heparanase investigated by protein engineering
The aim of this study was to investigate the mechanism of activation of human heparanase, a key player in heparan sulfate degradation, thought to be involved in normal and pathologic cell migration processes. Active heparanase arises as a product of a series of proteolytic processing events. Upon removal of the signal peptide, the resulting, poorly […]
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