Metabolic diseases

This Programme expands the scope of the Cardiometabolic diseases Programme and aims to study the processes that drive cells into dysmetabolic states. Addressing this question requires the integration of molecular mechanisms with the regulation of metabolism across scales, from the molecular and subcellular (organelles) to the organ scale and organism physiology.

HT scientists will investigate two broad areas of metabolic dysregulation: metabolic-associated liver diseases and hormonal metabolic regulation in the central nervous system. The former will focus on the identification of molecular mechanisms leading to dysmetabolic regulation in various types of liver diseases (for example, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, primary biliary cholangitis, and ciliopathies). The latter will investigate the impact of endocrine and metabolic disruption on brain development and health.

In addition, this programme will also touch upon nutritional and other metabolic diseases (e.g. obesity) as well as the role of nutrition in disease aetiology. As such, it will interface with other Flagship Research Programmes (for example, “Cardiometabolic diseases” and “Evolving diseases – Cancer”).