Nereo Kalebic
- Research Group Leader, Kalebic Group
Nereo Kalebic is a Group Leader at the Centre for Neurogenomics. He obtained his degree in Molecular Biology at the University of Zagreb in Croatia in 2007. In 2012 he completed his PhD in Molecular Biology at the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg. During his PhD, Nereo studied the role of microtubule post-translational modifications in development and function of nervous system. From 2013 to 2019, he carried out post-doctoral research in the group of Wieland Huttner at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden studying the development and evolution of human neocortex. Nereo’s current research focuses on molecular and cell biological mechanisms underlying human neocortex development and its implications for human evolution and neurodevelopmental disorders.
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Publications
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11/2024 - Life Science Alliance
Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor–tumor connections
Glioblastoma is a major unmet clinical need characterized by striking inter- and intra-tumoral heterogeneity and a population of glioblastoma stem cells (GSCs), conferring aggressiveness and therapy resistance. GSCs communicate through a network of tumor–tumor connections (TTCs), including nanotubes and microtubes, promoting tumor progression. However, very little is known about the mechanisms underlying TTC formation and […]
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09/2024 - Nature Methods
Serialized on-grid lift-in sectioning for tomography (SOLIST) enables a biopsy at the nanoscale
Cryo-focused ion beam milling has substantially advanced our understanding of molecular processes by opening windows into cells. However, applying this technique to complex samples, such as tissues, has presented considerable technical challenges. Here we introduce an innovative adaptation of the cryo-lift-out technique, serialized on-grid lift-in sectioning for tomography (SOLIST), addressing these limitations. SOLIST enhances throughput, […]
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06/2023 - EMBO Reports
DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression
Cortical neurogenesis depends on the balance between self-renewal and differentiation of apical progenitors (APs). Here, we study the epigenetic control of AP’s division mode by focusing on the enzymatic activity of the histone methyltransferase DOT1L. Combining lineage tracing with single-cell RNA sequencing of clonally related cells, we show at the cellular level that DOT1L inhibition […]
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09/2022 - Science
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
INTRODUCTION The evolutionary expansion of the neocortex and the concomitant increase in neuron production are considered to be a basis for the increase in cognitive abilities that occurred during human evolution. Endocast analyses reveal that the endocranial volume of modern humans and Neanderthals was similar, suggesting similar brain and neocortex size. But whether similar neocortex […]
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06/2022 - Frontiers in Cell and Developmental Biology
Forebrain Organoids to Model the Cell Biology of Basal Radial Glia in Neurodevelopmental Disorders and Brain Evolution
The acquisition of higher intellectual abilities that distinguish humans from their closest relatives correlates greatly with the expansion of the cerebral cortex. This expansion is a consequence of an increase in neuronal cell production driven by the higher proliferative capacity of neural progenitor cells, in particular basal radial glia (bRG). Furthermore, when the proliferation of […]
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