- Research group leader, Kalebic Group
Nereo Kalebic is a Group Leader at the Centre for Neurogenomics. He obtained his degree in Molecular Biology at the University of Zagreb in Croatia in 2007. In 2012 he completed his PhD in Molecular Biology at the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg. During his PhD, Nereo studied the role of microtubule post-translational modifications in development and function of nervous system. From 2013 to 2019, he carried out post-doctoral research in the group of Wieland Huttner at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden studying the development and evolution of human neocortex. Nereo’s current research focuses on molecular and cell biological mechanisms underlying human neocortex development and its implications for human evolution and neurodevelopmental disorders.
09/2021 - Development
Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution
Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular and morphological features of cell polarity may be inherited from one type of progenitor cell to the other and finally transmitted to neurons. Furthermore, […]
04/2021 - Frontiers
The neocortex is the largest part of the cerebral cortex and a key structure involved in human behavior and cognition. Comparison of neocortex development across mammals reveals that the proliferative capacity of neural stem and progenitor cells and the length of the neurogenic period are essential for regulating neocortex size and complexity, which in turn […]
10/2020 - Neuron
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.
Evolutionary expansion of the mammalian neocortex (Ncx) has been linked to increased abundance and proliferative capacity of basal progenitors (BPs) in the subventricular zone during development. BP proliferation is governed by both intrinsic and extrinsic signals, several of which have been identified. However, a role of neurotransmitters, a canonical class of extrinsic signaling molecules, in […]
08/2020 - Trends in Neuroscience
The evolutionary expansion of the neocortex is thought to be largely the consequence of an increase in the proliferative capacity of a specific class of neural progenitors called basal progenitors (BPs). Here we propose that BP morphology is a key cell biological feature underlying the increase in BP proliferative capacity. During neocortical expansion, BPs show […]
05/2020 - Journal of Visualized Experiments
Presented here is a protocol to perform genetic manipulation in the embryonic ferret brain using in utero electroporation. This method allows for targeting of neural progenitor cells in the neocortex in vivo.