Gaia Pigino
- Associate Head of Structural Biology Research Centre, Structural biology
- Research Group Leader, Pigino Group
Gaia Pigino is a biologist, currently Associate Head of the Structural Biology Center at Human Technopole, after 9 years as Research Group Leader at the Max Planck Institute CBG in Dresden. She collaborate with Alessandro Vannini to develop the Centre for Structural Biology. Gaia’s laboratory studies molecular mechanisms and principles of self-organisation in cilia and other subcellular structures that are of fundamental importance for human health and disease.
CURRENT POSITION
| Since 2021 | Associate Head of the Structural Biology Center at Human Technopole, Milan, Italy |
| Since 2012 | Research Group Leader at MPI-CBG, the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
POSTDOCTORAL RESEARCH
| 2010-2012 | Postdoctoral EMBO Long Term fellow Laboratory of Biomolecular Research (BMR), Department of Biology and Chemistry, Paul Scherer Institute (PSI) Switzerland. Supervisor: Prof. T. Ishikawa. |
| 2009-2011 | Postdoctoral researcher Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland. Supervisor: Prof. T. Ishikawa. |
| 2007-2009 | Postdoctoral MIUR research fellow Fellowship of the “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”. Laboratory of Cryotechniques for Electron Microscopy, Department of Evolutionary Biology, University of Siena. Supervisor: Prof. P. Lupetti. |
| 2009 | Participant at the Physiology Course at MBL in Woods Hole Marine Biological Laboratory, Woods Hole. Directors: Dyche Mullins and Claire Waterman. |
EDUCATION
| 2003-2007 | Ph.D. Student (Ph.D. Fellowship by the Italian government “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”). Department of Evolutionary Biology, University of Siena. Supervisor: Prof. F. Bernini and Prof. C. Leonzio. |
| 2002 | Diploma in Natural Science (Summa cum laude). University of Siena, Italy. Thesis supervisors: Prof. C. Leonzio and Prof. F. Bernini. |
OTHER POSITIONS
| 2003 | Research Associate. Department of Environmental Sciences G. Sarfatti, University of Siena. Advisor: Prof. C. Leonzio |
AWARDS and FUNDING
| 2022 | EMBO Member |
| 2019 | DFG Grant – GAČR-DFG Cooperation |
| 2018 | PoL starting fellowship (from the Dresden Excellence Cluster ‘Physics of Life’) |
| 2018 | Keith R. Porter Fellow Award for Cell Biology |
| 2018 | ERC Consolidator Grant (ERC-2018-COG N#819826 CiliaTubulinCode) |
| 2018 | Excellence Cluster ‘Physics of Life’, as a core Principal Investigator |
| 2010 | EMBO Long Term fellowship |
| 2009 | Scholarship from the Marine Biological Laboratory (Woods Hole, Massachusetts) MBL Physiology Course. |
| 2007 | Post-Doctoral Research fellowship from MIUR. |
| 2003 | Ph.D. Fellowship from MIUR. |
Fellowship to students and postdocs
| 2022 | EMBO Long Term Fellowship to Helen Foster |
| 2021 | EMBO Postdoc Fellowship to Nikolai Klena |
| 2019 | HFSP Postdoc Fellowship to Adrian Nievergelt |
| 2018 | EMBO Long Term Fellowship to Adrian Nievergelt |
| 2017 | Marie Curie Fellowship to Adam Schröfel (H2020-MSCA-IF-2016) |
| 2015 | DIGS-BB Fellowship to Guendalina Marini |
| 2012 | DIGS-BB Fellowship to Ludek Stepanek |
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Publications
- 01/2023 - Nature Structural & Molecular Biology
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and signaling cargos to microtubule motors for import into cilia. It remains unknown how the IFT-A/-B proteins are arranged into complexes and how these complexes polymerize into functional trains. Here […]
- 11/2022 - eLife
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex
Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential for development and homeostasis in organisms ranging from algae to vertebrates. In humans, variants in genes encoding subunits of the cargo-adapting IFT-A and IFT-B protein complexes are a common cause of genetic diseases known as ciliopathies. While recent progress has […]
- 10/2022 - Annu Rev Cell Dev Biol
Structural Biology of Cilia and Intraflagellar Transport
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal dynein motors and other complexes to achieve beating. Primary cilia are immotile and act as signaling hubs, with receptors shuttling between the cytoplasm and ciliary compartment. In both cilia types, […]
- 09/2022 - Current Biology
Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport
Cilia or eukaryotic flagella are microtubule-based organelles found across the eukaryotic tree of life. Their very high aspect ratio and crowded interior are unfavorable to diffusive transport of most components required for their assembly and maintenance. Instead, a system of intraflagellar transport (IFT) trains moves cargo rapidly up and down the cilium (Figure 1A).1, 2, 3 Anterograde IFT, from the cell body to the […]
- 08/2022 - BioRxiv
The Molecular Structure of Anterograde Intraflagellar transport trains
Anterograde intraflagellar transport trains are essential for cilia assembly and maintenance. These trains are formed of 22 IFTA and IFTB proteins that link structural and signalling cargoes to microtubule motors for import into cilia. It remains unknown how the IFTA/B proteins are arranged into complexes and how these complexes polymerise into functional trains. Here, we […]
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