Publications

With the impressive growth of available data and the flexibility of network modelling, the problem of devising effective quantitative methods for the comparison of networks arises. Plenty of such methods have been designed to accomplish this task: most of them deal with undirected and unweighted networks only, but a few are capable of handling directed […]

How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu elements (AEs) and RNA polymerase III transcription factor C (TFIIIC) in structurally and functionally modulating the genome via chromatin looping and histone acetylation. Upon serum deprivation, a subset […]

Applied sciences have witnessed an explosion of georeferenced data. Object oriented spatial statistics (O2S2) is a recent system of ideas that provides a solid framework where the new challenges posed by the GeoData revolution can be faced, by grounding the analysis on a powerful geometrical and topological approach. We shall present a perspective on O2S2, […]

This paper introduces a new empirical procedure for the estimation of hospitals’ technical efficiency in presence of spatial heterogeneity. We propose a methodology that allows treating spatial heterogeneity independently of a predetermined reference to administrative borders. We define geographical spatial regimes, characterised by spatial proximity and homogeneity of relevant demand characteristics, within which to assess […]