Zerial Group
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Il Gruppo Zerial studia l’endocitosi, il processo tramite il quale le cellule assorbono sostanze dall’ambiente extracellulare inglobandole in vescicole. La nostra ricerca attraversa le scale biologiche e le discipline per decifrare le interazioni tra proteine all’interno del macchinario di fusione endosomiale, definire i processi che stabiliscono la polarità degli epatociti e comprendere la biofisica della formazione del tessuto epatico. Infine, sfruttiamo la nostra conoscenza della delicata interazione tra forze, molecole e cellule per trovare soluzioni innovative per il delivery di farmaci.
Per maggiori informazioni sulla ricerca di Zerial, visita il sito web del Gruppo.
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Photo credits: Nuno Pimpao Martins / MPI-CBG. A sinistra: sezione di tessuto epatico di topo adulto colorato con actina. I confini delle cellule tra due grandi vene sono evidenziati in verde. A destra: ricostruzione tridimensionale dei confini degli epatociti, le principali cellule metaboliche del fegato.
Membri del gruppo
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Marino Zerial
Director
Pubblicazioni
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09/2005 - Cell
Rab Conversion as a Mechanism of Progression from Early to Late Endosomes
The mechanisms of endosome biogenesis and maintenance are largely unknown. The small GTPases Rab5 and Rab7 are key determinants of early and late endosomes, organizing effector proteins into specific membrane subdomains. Whether such Rab machineries are indefinitely maintained on membranes or can disassemble in the course of cargo transport is an open question. Here, we […]
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08/1999 - Cell
Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13
SNAREs and Rab GTPases cooperate in vesicle transport through a mechanism yet poorly understood. We now demonstrate that the Rab5 effectors EEA1 and Rabaptin-5/Rabex-5 exist on the membrane in high molecular weight oligomers, which also contain NSF. Oligomeric assembly is modulated by the ATPase activity of NSF. Syntaxin 13, the t-SNARE required for endosome fusion, […]
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02/1999 - Nature
The Rab5 effector EEA1 is a core component of endosome docking
Intracellular membrane docking and fusion requires the interplay between soluble factors and SNAREs. The SNARE hypothesis1 postulates that pairing between a vesicular v-SNARE and a target membrane z-SNARE is the primary molecular interaction underlying the specificity of vesicle targeting as well as lipid bilayer fusion. This proposal is supported by recent studies using a minimal artificial […]
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09/1992 - Cell
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
We have investigated the in vivo functional role of rab5, a small GTPase associated with the plasma membrane and early endosomes. Wild-type rab5 or rab5ile 133, a mutant protein defective in GTP binding, was overexpressed in baby hamster kidney cells. In cells expressing the rab5ile 133 protein, the rate of endocytosis was decreased by 50% […]
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07/1990 - Cell
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1SEC4 gene products have been isolated from an MDCK cell cDNA library. We localized three of the corresponding proteins in mammalian cells by using affinity-purified antibodies in immunofluorescence and immunoelectron microscopy studies. One, the MDCK homolog of rab2, is associated […]
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