Andrea Graziadei

Andrea Graziadei è un biologo strutturale e bioinformatico strutturale specializzato in modellistica integrativa e spettrometria di massa crosslinking.

BREVE CV:
Dal 2022 Senior Manager, Structural Proteomics SSU – Human Technopole

2019-2022 PostDoc – Technische Universität Berlin (Berlino, DE)
Mentore: Prof. Juri Rappsilber

2019 Dottorato di ricerca in biologia strutturale – European Molecular Biology Laboratory, (Heidelberg, DE)
Mentore: Dr. Teresa Carlomagno

Contatti

[email protected]

Pubblicazioni

  • 07/2020 - Science

    In-cell architecture of an actively transcribing-translating expressome

    In bacteria, RNA polymerases can associate with ribosomes to form transcription-translation units called expressomes. Multiple models based on structural data of in vitro reconstitution assays have been proposed for how the two machineries interface with one another. Understanding this bacteria-specific coupling mechanism offers insight regarding the central dogma of molecular biology and might be leveraged […]

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  • 05/2020 - eLife

    The guide sRNA sequence determines the activity level of box C/D RNPs

    2’-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA-guided manner. Despite the conservation of the methylation sites, the abundance of site-specific modifications shows variability across species and tissues, suggesting that rRNA methylation may provide a means of controlling gene expression. As all Box C/D […]

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