Fabio Marcuccio

I am a postdoctoral researcher at the Genomics Research Centre – Functional Genomics Programme at Human Technopole. I hold a PhD in Bionanotechnology from the University of Leeds, United Kingdom.

I graduated in Biomedical Engineering in 2018 from Politecnico di Torino. In 2017, I moved to the United States to work on my master’s thesis at Johns Hopkins University, Maryland, under the supervision of Prof. Ralph Etienne-Cummings from the Whiting School of Engineering, and Dr. Alena Savonenko from the School of Medicine.

In 2019, I moved to the United Kingdom for my doctoral studies as a Marie-Sklodowska Curie PhD fellow at the University of Leeds, West Yorkshire, under the supervision of Dr. Paolo Actis from the Bragg Centre for Materials Research, and Prof. Lucy Stead from the Leeds Institute of Medical Research at St. James’s. During my PhD, I was part of an Innovative Training Network focused on developing nanotechnologies for single-entity analysis. At Leeds, I collaborated with biologists and bioinformaticians on a nanopipette-based technique to perform cytoplasmic nanobiopsies on individual glioblastoma cells, longitudinally, across standard therapy, for downstream gene expression profiling and trajectory analysis. This experience was pivotal in driving my passion for RNA biology and sequencing. Additionally, I worked on single-molecule techniques and numerical modelling to improve the signal-to-noise ratio in the detection of DNA and RNA using solid-state nanopores.

After obtaining my PhD, I moved to Imperial College London to work in the Nanomedicine lab under the supervision of Dr. Andrew Shevchuk and Prof. Yuri Korchev, focusing on nanopipette approaches for the analysis and manipulation of individual mammalian cells. While in London, I developed an electroporation-based nanoinjection technique for the compartmental delivery of exogenous molecules into the nucleus and/or cytoplasm of individual mammalian cells.

In 2024, I joined Human Technopole as a postdoctoral researcher in the laboratory for Molecular and Systems Biology of RNA. My current research uses an interdisciplinary approach involving advanced microscopy, RNA sequencing, and mathematical modelling to study the mechanisms of RNA metabolism and homeostasis. In particular, I am studying the role of poly(A)-binding proteins in regulating the transcription and degradation of mRNA to ensure the maintenance of mRNA homeostasis within a mammalian cell.