First Open Framework for Linking Rare Disease and Environmental Data
A multidisciplinary team led out of the ADAPT Centre at Trinity College Dublin has published cutting-edge research on a new tool designed to enable efficient data linkages between rare diseases and environmental datasets. Published recently in Nature Digital Medicine, the researchers present SERDIF (Semantic Environmental and Rare Disease data Integration Framework), an innovative framework that enables health data researchers to efficiently link environmental and health data sources through location and time information.
HT Director Zerial Awarded Mercurio Prize for Excellence in Research
The Human Technopole Director, Marino Zerial, has been awarded the 2024 Mercurio Prize in the “Research and Development” category, in recognition of the excellence of his research in the field of cell biology. Zerial, renowned for his studies on the mechanisms of endocytosis and cellular transport, has made significant contributions to the understanding of cellular dynamics, with potential therapeutic applications for diseases such as liver conditions.
A new model system for cortical development in vitro
Researchers from Human Technopole, the Institute of Molecular Biotechnology and Bicocca University established a method for developing brain assembloids that allows reproducing salient aspects of the antero-posterior polarity of the human cerebral cortex in vitro and opens new possibilities for disease modelling. The study is published in Nature Methods.
The National Facility for Genomics with Clelia Peano
Meet Clelia Peano, Head of the National Facility for Genomics. The Facility offers cutting-edge services to develop robust experimental and analytical workflows to explore different genomic research areas, including DNA and RNA analysis, chromatin structure, and epigenetic mechanisms regulating transcription. The goal is to enhance genomic research in all its aspects, benefiting the entire Italian scientific community.
SOLIST: Towards a Biopsy at the Nanoscale
Human Technopole researchers have developed an improved cryo-lift out technique: Serialized On-grid Lift-in Sectioning for Tomography (SOLIST). SOLIST is a significant upgrade over previous approaches and allows imaging tissues to reveal their native organization at a molecular level with a throughput previously impossible. The results of the research are published in Nature Methods.
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