On 1 September 2023 the Human Technopole community warmly welcomed Marino Zerial as he officially took office as the institute’s new Director.
Following 25 years in Dresden where he served as Director of the Max Planck Institute of Molecular Cell Biology and Genetics, Marino was appointed as Human Technopole Director in February 2023 by the Foundation’s Consiglio di Sorveglianza following a global call for applications managed by a Search Committeee composed of international experts.
Over the past few months, he has visited Milan and Human Technopole on multiple occasions to meet with HT Faculty and Scientific Committee and coordinate a smooth transition with his predecessor prof. Iain Mattaj.
Among the first priorities of his Directorate are the drafting of a new Strategic Plan for 2024-2028, the opening of National Facilities to the national research community and the expansion of the HT campus with the construction of the new building.
An international collaborative study led by Human Technopole, Candiolo Cancer Institute IRCCS in Turin, the University of Turin, and the Wellcome Sanger Institute in Cambridge (UK) has identified new factors associated with therapeutic response in colorectal cancer. The research has led to the development of a machine-learning model capable of accurately predicting the effects of cetuximab, a drug in clinical use, on different colorectal tumour subtypes. Funded by the AIRC Foundation, the study paves the way to identifying molecular features that could serve as biomarkers for predicting treatment response in patients with this type of cancer.
The Human Technopole Director, Marino Zerial, has been awarded the 2024 Mercurio Prize in the “Research and Development” category, in recognition of the excellence of his research in the field of cell biology. Zerial, renowned for his studies on the mechanisms of endocytosis and cellular transport, has made significant contributions to the understanding of cellular dynamics, with potential therapeutic applications for diseases such as liver conditions.
Researchers from Human Technopole, the Institute of Molecular Biotechnology and Bicocca University established a method for developing brain assembloids that allows reproducing salient aspects of the antero-posterior polarity of the human cerebral cortex in vitro and opens new possibilities for disease modelling. The study is published in Nature Methods.
Meet Clelia Peano, Head of the National Facility for Genomics. The Facility offers cutting-edge services to develop robust experimental and analytical workflows to explore different genomic research areas, including DNA and RNA analysis, chromatin structure, and epigenetic mechanisms regulating transcription. The goal is to enhance genomic research in all its aspects, benefiting the entire Italian scientific community.
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