Publications

Presented here is a protocol to perform genetic manipulation in the embryonic ferret brain using in utero electroporation. This method allows for targeting of neural progenitor cells in the neocortex in vivo.

Exposure to multiple synthetic chemicals is a permanent feature of modern life. Many of these chemicals are suspected to disrupt endocrine systems of humans and animals. Endocrine disrupting chemicals (EDCs) act at very low concentrations and non-linearly, defying mainstream single-substance chemical regulation. Here we provide an analysis of findings from the first phase of the […]

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug. These evolutionary trade-offs can be exploited using ‘evolutionary steering’ to control the tumour population and delay resistance. However, recapitulating cancer […]