Di Angelantonio & Ieva Group
In the Di Angelantonio & Ieva Group, epidemiologists, statisticians and data scientists work together to bridge the gap between genotype and phenotype by studying multiple layers of biomolecular data to investigate health from molecules to diseases. To achieve this aim, we develop innovative studies to integrate and link biomolecular data with electronic health records (EHRs), imaging, wearable and other data. We use already available data (e.g. hospital records, prescription records, cohort studies), generate new data from population studies and develop new analytical methods integrated with clinical epidemiology and healthcare research to improve data analysis and interpretation.
By linking molecular and health records, our research will offer major actionable insights into several fields including biology, disease aetiology, risk prediction, early detection, and therapeutic targeting. The methodological approaches we develop will be applied to personalized medicine, with benefits for individual patients’ health, as well as to larger health studies by leveraging the power of large-scale data, with remarkable advances for public health, health data analytics and the development of targeted policy interventions.
Current areas of research include understanding of causal risk factors and development of risk prediction models for non-communicable diseases, using novel analytical approaches to combine different levels of information including omics, genetics and electronic health records.
Group members
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Emanuele Di Angelantonio
Head of Health Data Science Centre -
Francesca Ieva
Associate Head of Research centre -
Laura Bondi
Postdoc -
Solène Cadiou
Postdoc -
Andrea Corbetta
PhD Student -
Nicole Fontana
PhD Student -
Andrea Lampis
PhD Student -
Katherine Marie Logan
PhD Student -
Alessia Mapelli
PhD Student -
Michela Carlotta Massi
Staff Scientist -
Lucia Piubeni
PhD Student -
Carlo Andrea Pivato
Scientific Visitor -
Laura Savarè
Postdoc -
Piercesare Secchi
Scientific Visitor -
Luca Trizio
Scientific Visitor -
Andrea Mario Vergani
PhD Student
Publications
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09/2022 - PloS CompBio
Deep Survival EWAS approach estimating risk profile based on pre-diagnostic DNA methylation: an application to Breast Cancer time to diagnosis
Previous studies for cancer biomarker discovery based on pre-diagnostic blood DNA methylation profiles, either ignore the explicit modeling of the time to diagnosis (TTD) as in a survival analysis setting, or provide inconsistent results. This lack of consistency is likely due to the limitations of standard EWAS approaches, that model the effect of DNAm at […]
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08/2022 - European Journal of Preventive Cardiology
Obesity and cardiovascular disease: mechanistic insights and management strategies. A joint position paper by the World Heart Federation and World Obesity Federation
The ongoing obesity epidemic represents a global public health crisis that contributes to poor health outcomes, reduced quality of life, and >2.8 million deaths each year. Obesity is relapsing, progressive, and heterogeneous. It is considered a chronic disease by the World Obesity Federation (WOF) and a chronic condition by the World Heart Federation (WHF). People […]
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08/2022 - European Journal of Preventive Cardiology
Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP
Aims The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) […]
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08/2022 - European Journal of Nuclear Medicine and Molecular Imaging
PET/CT-based radiomics of mass-forming intrahepatic cholangiocarcinoma improves prediction of pathology data and survival
Purpose Intrahepatic cholangiocarcinoma (IHC) is an aggressive disease with few reliable preoperative biomarkers. This study aims to elucidate if radiomics extracted from preoperative [18F]FDG PET/CT may grant a non-invasive biological characterization of IHC and predict outcome after complete resection of the tumor. Methods All patients preoperatively imaged by [18F]FDG PET/CT who underwent hepatectomy for mass-forming […]
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06/2022 - Statistical Methods & Applications
Modelling time-varying covariates effect on survival via functional data analysis: application to the MRC BO06 trial in osteosarcoma
Time-varying covariates are of great interest in clinical research since they represent dynamic patterns which reflect disease progression. In cancer studies biomarkers values change as functions of time and chemotherapy treatment is modified by delaying a course or reducing the dose intensity, according to patient’s toxicity levels. In this work, a Functional covariate Cox Model […]