Alessandro Vannini
- Head of Structural Biology Research Centre, Biologia Strutturale
- Research Group Leader, Vannini Group
Alessandro Vannini è un biochimico. Dirige il Centro di Biologia Strutturale dopo quasi otto anni passati nel Regno Unito in qualità di Principal Investigator e Deputy Head of Division all’Institute of Cancer Research di Londra.
Il suo laboratorio si occupa di studiare in dettaglio i meccanismi molecolari di complessi proteici che vengono assemblati intorno a siti di legame per la RNA Polymerase III e che giocano un ruolo fondamentale nella regolazione dell’espressione genica e nella organizzazione strutturale del genoma eucariotico. Questi meccanismi sono spesso deregolati in patalogie umane, quali il cancro e malattie neurodegenerative congenite.
Email: alessandro.vannini[at]fht.org
Contatti
Segui
Pubblicazioni
-
11/2023 - Cell Reports Medicine
RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fueled the COVID-19 pandemic with its enduring medical and socioeconomic challenges because of subsequent waves and long-term consequences of great concern. Here, we chart the molecular basis of COVID-19 pathogenesis by analyzing patients’ immune responses at single-cell resolution across disease course and severity. This […]
-
11/2022 - Nature Structural & Molecular Biology
Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II
RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes. Whereas Pol II initiation at protein-coding genes has been studied in detail, Pol II initiation at non-coding genes, such as small nuclear RNA (snRNA) genes, is less well understood at the structural level. Here, we study Pol II initiation at snRNA […]
-
09/2022 - Life Sci Alliance
The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans
Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we present the purification of human Pol I from cells carrying a genomic GFP fusion on the largest subunit allowing the structural and functional analysis of the enzyme […]
-
12/2021 - Elife
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
Dramatic change in chromosomal DNA morphology between interphase and mitosis is a defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops. While condensin normally configures chromosomes exclusively during mitosis, cohesin does so during interphase. The processivity of cohesin’s loop […]
-
11/2021 - Nature Communications
Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
Retrotransposons are endogenous elements that have the ability to mobilise their DNA between different locations in the host genome. The Ty3 retrotransposon integrates with an exquisite specificity in a narrow window upstream of RNA Polymerase (Pol) III-transcribed genes, representing a paradigm for harmless targeted integration. Here we present the cryo-EM reconstruction at 4.0 Å of […]
Previous page