Ilaria Bertani
- Senior Research Technician, Kalebic Group
Pubblicazioni
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09/2025 - Cell Reports
Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis
The evolutionary expansion of the mammalian neocortex is driven by increased proliferative capacity of neural progenitor cells. However, the molecular machinery controlling the proliferation of apical and basal progenitors during neocortical development remains poorly understood. Here, we show that the three actin-associated morpho-regulatory adducins (ADD1–3) underlie the abundance of basal progenitors in the developing ferret […]
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11/2024 - Life Science Alliance
Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor–tumor connections
Glioblastoma is a major unmet clinical need characterized by striking inter- and intra-tumoral heterogeneity and a population of glioblastoma stem cells (GSCs), conferring aggressiveness and therapy resistance. GSCs communicate through a network of tumor–tumor connections (TTCs), including nanotubes and microtubes, promoting tumor progression. However, very little is known about the mechanisms underlying TTC formation and […]
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06/2023 - EMBO Reports
DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression
Cortical neurogenesis depends on the balance between self-renewal and differentiation of apical progenitors (APs). Here, we study the epigenetic control of AP’s division mode by focusing on the enzymatic activity of the histone methyltransferase DOT1L. Combining lineage tracing with single-cell RNA sequencing of clonally related cells, we show at the cellular level that DOT1L inhibition […]