Samuel Edward Lacey
- Postdoc, Pigino Group
Contatti
Pubblicazioni
-
08/2024 - Cell
Extensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, called anterograde and retrograde intraflagellar transport (IFT) trains. Anterograde trains deliver cargoes from the cell to the cilium tip, then convert into retrograde trains for cargo export. We set out to understand how the IFT complexes can perform these two […]
-
01/2023 - Nature Structural & Molecular Biology
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and signaling cargos to microtubule motors for import into cilia. It remains unknown how the IFT-A/-B proteins are arranged into complexes and how these complexes polymerize into functional trains. Here […]
-
08/2022 - BioRxiv
The Molecular Structure of Anterograde Intraflagellar transport trains
Anterograde intraflagellar transport trains are essential for cilia assembly and maintenance. These trains are formed of 22 IFTA and IFTB proteins that link structural and signalling cargoes to microtubule motors for import into cilia. It remains unknown how the IFTA/B proteins are arranged into complexes and how these complexes polymerise into functional trains. Here, we […]