01/2021 - Seizure activity and brain damage in a model of focal non‐convulsive status epilepticus
Aims Focal non‐convulsive status epilepticus (FncSE) is a common emergency condition that may present as the first epileptic manifestation. In recent years, it has become increasingly clear that de novo FncSE should be promptly treated to improve post‐status outcome. Whether seizure activity occurring during the course of the FncSE contributes to ensuing brain damage has not been demonstrated unequivocally […]
01/2021 - Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility beat, and male fertility
Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. Tubulin glycylation modifies microtubules specifically in cilia and flagella, but its functional and mechanistic roles remain unclear. In this study, we generated a mouse model entirely lacking tubulin […]
01/2021 - Human stem cell models to study host–virus interactions in the central nervous system
Advancements in human pluripotent stem cell technology offer a unique opportunity for the neuroimmunology field to study host–virus interactions directly in disease-relevant cells of the human central nervous system (CNS). Viral encephalitis is most commonly caused by herpesviruses, arboviruses and enteroviruses targeting distinct CNS cell types and often leading to severe neurological damage with poor […]
12/2020 - Structure of human RNA polymerase III
In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across eukaryotes. Upregulation of Pol III transcription is observed in cancer and causative Pol III mutations have been described in neurodevelopmental disorders and hypersensitivity to viral infection. […]
12/2020 - 3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells
This collaborative work is a good example for how members of our team can collaborate with biologists and technologists to improve the quantitative analysis work required to gain insights into essential processes related to human health and pathology, in this particular case into the subcellular organization of insulin producing β cells. Microtubules play a major […]
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