Pubblicazioni

Within the perimeter of patent collaboration networks, the average distance of collaborations and the number of countries involved per each collaboration have been shown to have increased steadily in time. Less attention, though, has been devoted to assessing whether this growth of cross-country collaborations is stable in time. To address this scientific question we focus […]

DNA fluorescence in situ hybridization (DNA FISH) is a powerful method to study chromosomal organization in single cells. At present, there is a lack of free resources of DNA FISH probes and probe design tools which can be readily applied. Here, we describe iFISH, an open-source repository currently comprising 380 DNA FISH probes targeting multiple […]

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspots in the vast majority of cells; this lack of coverage prevents the correlation of genetic and transcriptional readouts from the same single cell. To overcome this, […]

We propose a novel model for hierarchical time-to-event data, for example, healthcare data in which patients are grouped by their healthcare provider. The most common model for this kind of data is the Cox proportional hazard model, with frailties that are common to patients in the same group and given a parametric distribution. We relax […]

This work evaluates the predictive ability of a novel personalized computational tool for simulating the growth of brain tumours using the neuroimaging data collected during one clinical case study. The mathematical model consists of an evolutionary fourth-order partial differential equation with degenerate motility, in which the spreading dynamics of the multiphase tumour is coupled with […]